基本信息：
姓名：高成江
职称：教授
导师：博士生导师
院系：基础医学院免疫学系
专业领域：固有免疫活化与炎症调控
电话：0531-88382292
邮箱:cgao@sdu.edu.cn
地址：山东济南市文化西路44号，6号楼6222房间
学习与工作经历：
2007.10-今 山东大学基础医学院，教授
2002.08-2007.10 美国杜克大学，博士后
2001.02-2002.08 美国加州大学戴维斯分校，博士后
1995.09-2000.12 中国科学院上海植物生理研究所，博士
1991.09-1995.06 山东大学生物系，学士
研究方向和研究内容：
病毒、细菌和真菌等病原微生物感染严重危害人类健康，固有免疫是机体抵抗病原微生物感染的第一道防线，其识别活化对于机体有效清除感染并维持机体稳态防止病理损伤至关重要。实验室主要从事抗感染固有免疫识别活化和炎症反应的调控机制研究，聚焦蛋白质翻译后修饰包括蛋白质泛素化修饰等在抗感染固有免疫识别活化和炎症反应中的功能和调控机制。研究结果将揭示固有免疫识别活化的新型调控机制，完善固有免疫识别活化和炎症反应的调控网络，并为感染性疾病和炎症相关疾病的治疗和预防提供理论指导。
科研项目（含人才类项目）：
1. 国家自然科学基金委，重点项目，32530035，神经递质调控抗真菌免疫应答的分子机制研究，2026/01-2030/12, 主持，220万元，在研。
2. 国家自然科学基金委，创新研究群体项目，82321002，固有免疫稳态调控，2024/01-2028/12, 主持，1000万元，在研。
3. 国家自然科学基金委，重点项目，32230033，核糖体相关质量控制体系调控抗病毒天然免疫的分子机制研究，2023/01 – 2027/12，主持，272万元，在研。
4. 国家自然科学基金委，重点项目，81930039，蛋白质泛素化调控抗真菌免疫反应的分子机制研究，2020/01 – 2024/12, 主持，305万元，结题。
5. 国家自然科学基金委，重点项目，3173002，蛋白质翻译后修饰调控抗病毒天然免疫反应的机制研究，2018/01-2022/12, 主持，314万元，结题。
6. 国家自然科学基金委，杰出青年科学基金，81525012，抗病毒天然免疫，2016/01-2020/12，主持，400万元，结题。
7. 国家自然科学基金委，面上项目，81471538，泛素连接酶TRIM调控抗病毒天然免疫反应的机制研究，2015/01-2018/12，主持，80万元，结题。
8. 教育部，高等学校博士学科点专项科研基金（优先发展领域），20130131130010，抗病毒天然免疫的调节机制研究，2014/01-2016/12，主持，40万元，结题。
9. 国家自然科学基金委，面上项目，81273219，TRIP在抗病毒天然免疫中的作用及机制研究，2013/01-2016/12，主持，70万元，结题。
10. 国家自然科学基金委，面上项目，81172813，骨桥蛋白(OPN)对TLR3/4和RIG-I介导的IFN-β表达的调控作用及机制，2012/01-2015/12，主持，60万元，结题。
11. 山东省自然科学基金委，杰出青年科学基金，JQ201120，分子生物学及免疫学，2012/01-2014/12，主持，50万元，结题。
代表性成果：
1. Feng Y#, Cheng X#, Yang Y, Liu C, Shi Y, Qi X, Zhao W, Liu B, Chen T*, Gao Chengjiang*. TBK1 phagosomal recruitment enhances antifungal immunity via positive feedback regulation with SRC. Cell Rep. 2025, 44(7):115972.
2. Cao L, Zhang J, Yu L, Yang W, Qi W, Ren R, Liu Y, Hou Y, Cao Y, Li Q, Wang X, Zhang Z, Li B, Sui W, Zhang Y, Gao Chengjiang*, Zhang C*, Zhang M*. E3 ubiquitin ligase Listerin regulates macrophage cholesterol efflux and atherosclerosis by targeting ABCA1. J Clin Invest. 2025, 135(16):e186509.
3. Qin F#, Cao R#, Bai X, Yuan J, Sun W, Zheng Y, Qi X, Zhao W, Liu B*, Gao Chengjiang*. Listerin Alleviates Alzheimer's Disease through IRE1-mediated Decay of TLR4 mRNA. Adv Sci (Weinh). 2025, e14956.
4. Zheng Y, Gao Chengjiang*. Proteasome: An antibiotic arsenal in anti-bacterial innate immunity. Mol Cell. 2025, 85(10):1894-1896.
5. Bai X, Dong N, Cao N, Zhou M, Yuan J, Zhang Y, Liu Y, Zhang J, Chen T, Liu F, Sun W, Zheng Y, Zhao W, Shu Q, Gao Chengjiang*, Liu B*. ZNF593 regulates the cGAS-mediated innate immune response by attenuating cGAS-DNA binding. Cell Death Differ. 2025, 32(10):1845-1858.
6. Sun W#, Wu H#, Zhao G, Shui Q, Zhang L, Luan X, Chen T, Liu F, Zheng Y, Zhao W, Qi X, Liu B, Gao Chengjiang*. Lipid droplets restrict phagosome formation in antifungal immunity. Cell Mol Immunol. 2025, 22(5):468-484.
7. Liu Y, Zhang X, Yu L, Cao L, Zhang J, Li Q, Wang X, Qi W, Cai L, Ren R, Wang W, Guo X, Su G, Xi B, Zhang Y, Gao Chengjiang*, Zhang M*, Zhang C*. E3 ubiquitin ligase RNF128 promotes Lys63-linked polyubiquitination on SRB1 in macrophages and aggravates atherosclerosis. Nat Commun. 2025, 16(1):2185.
8. Qin F, Cao R, Cui W, Bai X, Yuan J, Zhang Y, Liu Y, Cao N, Dong N, Zhou M, Chen T, Liu F, Sun W, Zheng Y, Zhao W, Liu B*, Gao Chengjiang*. Listerin promotes α-synuclein degradation to alleviate Parkinson's disease through the ESCRT pathway. Sci Adv. 2025, 11(7):eadp3672.
9. Song X, Liu T, Yu L, Ji Q, Guo X, Zong R, Li Y, Huang G, Xue Q, Fu Q, Liu B, Zheng Y, Chen L, Gao Chengjiang*, Liu H*. OTUD5 Protects Dopaminergic Neurons by Promoting the Degradation of α-Synuclein in Parkinson's Disease Model. Adv Sci (Weinh). 2025, 12(7):e2406700.
10. Shao Z, Wang L, Cao L, Chen T, Jia XM, Sun W*, Gao Chengjiang*, Xiao H*. The protein segregase VCP/p97 promotes host antifungal defense via regulation of SYK activation. PLoS Pathog. 2024, 20(10):e1012674.
11. Zhao Z, Song X, Wang Y, Yu L, Huang G, Li Y, Zong R, Liu T, Ji Q, Zheng Y, Liu B, Zhu Q, Chen L, Gao Chengjiang*, Liu H*. E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model. Cell Death Differ. 2024, 31(11):1410-1421.
12. Zhang X, Han L, Hou J, Yang H, Xu H, Li G, Shu Q, Zhu D*, Zheng Y*, Gao Chengjiang*. Stress granule-localized USP8 potentiates cGAS-mediated type I interferonopathies through deubiquitination of DDX3X. Cell Rep. 2024, 43(6):114248.
13. Liu Y, Yuan J, Zhang Y, Qin F, Bai X, Sun W, Chen T, Liu F, Zheng Y, Qi X, Zhao W, Liu B*, Gao Chengjiang*. OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation. Cell Death Differ. 2024, 31(6):753-767.
14. Zhao G, Li Y, Chen T, Liu F, Zheng Y, Liu B, Zhao W, Qi X, Sun W*, Gao Chengjiang*. TRIM26 alleviates fatal immunopathology by regulating inflammatory neutrophil infiltration during Candida infection. PLoS Pathog. 2024, 20(1):e1011902.
15. Qin F, Cai B, Cao R, Bai X, Yuan J, Zhang Y, Liu Y, Chen T, Liu F, Sun W, Zheng Y, Qi X, Zhao W, Liu B*, Gao Chengjiang*. Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS-mediated immune response. Proc Natl Acad Sci U S A. 2023, 120(52):e2308853120.
16. Qin F, Cai B, Wang P, Cao R, Zhang Y, Wen H, Zheng Y, Zhao W, Gao Chengjiang*, Liu B*. LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway. Autophagy. 2024, 20(6):1270-1285.
17. Liu F, Zhuang W, Song B, Yang Y, Liu J, Zheng Y, Liu B, Zheng J, Zhao W, Gao Chengjiang*. MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade. Cell Mol Immunol. 2023, 20(10):1186-1202.
18. Chen T, Feng Y, Sun W, Zhao G, Wu H, Cheng X, Zhao F, Zhang L, Zheng Y, Zhan P, Zhao W, Liu B, Gao Chengjiang*. The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity. Immunity. 2023, 56(8):1727-1742.
19. Zheng Y, Zhang X, Gao Chengjiang*. PI4P STimulatING innate immune activation: beyond the Golgi. Cell Mol Immunol. 2023, 20(12):1399-1400.
20. Kong L, Sui C, Chen T, Zhang L, Zhao W, Zheng Y, Liu B, Cheng X*, Gao Chengjiang*. The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus. Cell Rep. 2023, 42(4):112306.
21. Liu H#, Yan Z#, Zhu D, Xu H, Liu F, Chen T, Zhang H, Zheng Y, Liu B, Zhang L, Zhao W, Gao Chengjiang*. CD-NTase family member MB21D2 promotes cGAS-mediated antiviral and antitumor immunity. Cell Death Differ. 2023, 30(4):992-1004.
22. Bai X, Sui C, Liu F, Chen T, Zhang L, Zheng Y, Liu B*, Gao Chengjiang*. The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation. Nat Commun. 2022, 13(1):5016.
23. Zhuang W, Zhang L, Zheng Y, Liu B, Ma C, Zhao W, Liu S, Liu F*, Gao Chengjiang*. USP3 deubiquitinates and stabilizes the adapter protein ASC to regulate inflammasome activation. Cell Mol Immunol. 2022, 19(10):1141-1152.
24. Zhang J, Cao L, Wang X, Li Q, Zhang M, Cheng C, Yu L, Xue F, Sui W, Sun S, Li N, Bu P, Liu B, Gao F, Zhen J, Su G, Zhang C, Gao Chengjiang*, Zhang M*, Zhang Y*. The E3 ubiquitin ligase TRIM31 plays a critical role in hypertensive nephropathy by promoting proteasomal degradation of MAP3K7 in the TGF-β1 signaling pathway. Cell Death Differ. 2022, 29(3):556-567.
25. Yan Z#, Wu H#, Liu H, Zhao G, Zhang H, Zhuang W, Liu F, Zheng Y, Liu B, Zhang L, Gao Chengjiang*. The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation. Cell Rep. 2021, 36(12):109731.
26. Cai B#, Zhao J#, Zhang Y, Liu Y, Ma C, Yi F, Zheng Y, Zhang L, Chen T, Liu B*, Gao Chengjiang*. USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3. Autophagy. 2021, 1-15.
27. Wang X#, Zhang H#, Shao Z, Zhuang W, Sui C, Liu F, Chen X, Hou J, Kong L, Liu H, Zheng Y, Liu B, Chen T, Zhang L, Jia X, Gao Chengjiang*. TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity. Signal Transduct Target Ther. 2021, 6(1):298.
28. Zeng S, Zhao Z, Zheng S, Wu M, Song X, Li Y, Zheng Y, Liu B, Chen L, Gao Chengjiang*, Liu H*. The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR. Redox Biol. 2021, 45:102058.
29. Qin F, Cai B, Zhao J, Zhang L, Zheng Y, Liu B*, Gao Chengjiang*. Methyltransferase-Like Protein 14 Attenuates Mitochondrial Antiviral Signaling Protein Expression to Negatively Regulate Antiviral Immunity via N6-methyladenosine Modification. Adv Sci (Weinh). 2021, 8(15):2100606.
30. Zhao J#, Cai B#, Shao Z, Zhang L, Zheng Y, Ma C, Yi F, Liu B*, Gao Chengjiang*. TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1. Cell Death Differ. 2021, 28(11):3077-3091.
31. Hou J, Han L, Zhao Z, Liu H, Zhang L, Ma C, Yi F, Liu B, Zheng Y*, Gao Chengjiang*. USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS. Nat Commun. 2021, 12(1):2970.
32. Chen X, Zhang H, Wang X, Shao Z, Li Y, Zhao G, Liu F, Liu B, Zheng Y, Chen T, Zheng H*, Zhang L*, Gao Chengjiang*. OTUD1 Regulates Antifungal Innate Immunity through Deubiquitination of CARD9. J Immunol. 2021, 206(8):1832-1843.
33. Guo Y#, Jiang F#, Kong L, Wu H, Zhang H, Chen X, Zhao J, Cai B, Li Y, Ma C, Yi F, Zhang L, Liu B, Zheng Y, Zhang L*, Gao Chengjiang*. OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING. Cell Mol Immunol. 2021, 18(8):1945-1955.
34. Guo Y, Jiang F, Kong L, Li B, Yang Y, Zhang L, Liu B, Zheng Y, Gao Chengjiang*. Cutting Edge: USP27X Deubiquitinates and Stabilizes the DNA Sensor cGAS to Regulate Cytosolic DNA-Mediated Signaling. J Immunol. 2019, 203(8):2049-2054.
35. Liu B, Gao Chengjiang*. Regulation of MAVS activation through post-translational modifications. Curr Opin Immunol. 2018, 50:75-81.
36. Liu B#, Zhang M#, Chu H, Zhang H, Wu H, Song G, Wang P, Zhao K, Hou J, Wang X, Zhang L, Gao Chengjiang*. The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination. Nat Immunol. 2017, 18(2):214-224.
37. Song H#, Liu B#, Huai W#, Yu Z, Wang W, Zhao J, Han L, Jiang G, Zhang L, Gao Chengjiang*, Zhao W*. The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3. Nat Commun. 2016, 7:13727.
38. Song G, Liu B, Li Z, Wu H, Wang P, Zhao K, Jiang G, Zhang L, Gao Chengjiang*. E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1. Nat Immunol. 2016, 17(12):1342-1351.
39. Wang P, Zhao W, Zhao K, Zhang L, Gao Chengjiang*. TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3. Plos Pathog. 2015, 11(3), e1004726.
40. Zhang L, Zhao X, Zhang M, Zhao W, Gao Chengjiang*. Ubiquitin-specific protease 2b negatively regulates IFN-β production and antiviral activity by targeting TANK-binding kinase 1. J Immunol. 2014, 193(5):2230-2237.
41. Wang L, Zhao W, Zhang M, Wang P, Zhao K, Zhao X, Yang S, Gao Chengjiang*. USP4 positively regulates RIG-I-mediated antiviral response through deubiquitination and stabilization of RIG-I. J Virol. 2013, 87(8):4507-4515.
42. Zhang M, Wang L, Zhao X, Zhao K, Meng H, Zhao W*, Gao Chengjiang*. TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. J. Exp. Med. 2012, 209(10): 1703-1711.
43. Qiao Y, Wang P, Qi J, Zhang L, Gao Chengjiang*. TLR-induced NF-κB activation regulates NLRP3 expression in murine macrophages. FEBS Lett. 2012, 586(7):1022-1026.
44. Zhao W, Wang L, Zhang M, Wang P, Yuan C, Qi J, Meng H, Gao Chengjiang*. Tripartite motif-containing protein 38 negatively regulates TLR3/4- and RIG-I-mediated IFN-β production and antiviral response by targeting NAP1. J Immunol. 2012, 188(11):5311-5318.
45. Yuan C, Qi J, Zhao X, Gao Chengjiang*. Smurf1 protein negatively regulates interferon-γ signaling through promoting STAT1 protein ubiquitination and degradation. J Biol Chem. 2012, 287(21):17006-17015.
46. Zhao W, Wang L, Zhang M, Yuan C, Gao Chengjiang*. E3 ubiquitin ligase tripartite motif 38 negatively regulates TLR-mediated immune responses by proteasomal degradation of TNF receptor-associated factor 6 in macrophages. J Immunol. 2012, 188(6):2567-2574.
转化应用：
1. 发明专利，2024年07月09日，一种靶向Src激酶的短肽及其在系统性真菌感染中的应用，中国，1/8，ZL 2023 1 0619462.0
2. 发表专利，2021年12月24日，靶向IKKβ的短肽及其在炎症性疾病中的应用，中国，1/7，ZL 2020 1 0676788.3
授课情况：
1.本科生课程：《感染免疫与相关疾病》
2.研究生课程：《医学分子免疫学》
学术/社会兼职：
《Molecular Immunology》杂志副主编（Associate editor）（2018-今）
《Cellular and Molecular Immunology》杂志编委（Editorial Board）（2018-今）
《Cell Reports》Advisory Board (2025.03-今)
《Cell Insights》杂志编委（Editorial Board）（2025-今）
中国免疫学会常务理事（2024.10-今）
中国免疫学会基础免疫分会副主任委员（2023.04-今）
山东省免疫学会理事长（2022.09-今）
中国细胞生物学学会常务理事（2023.04-今）
山东省细胞生物学学会副理事长（2018.08-今）
世界华人医师协会世界华人医学真菌专业委员会常务理事（2024.10-今）
山东省感染免疫与疾病干预重点实验室主任（2024-今）
中华医学会微生物学与免疫学分会常务理事（2025.01-今）
山东省医学会常务理事（2022.10-今）
山东省优秀博士学位论文指导教师（2014,2017,2018,2021）
山东省优秀硕士学位论文指导教师（2013）
获奖荣誉：
1. 2022年，教育部高等学校科学研究优秀成果奖自然科学一等奖（第一位）
2. 2018年，国家科学技术进步奖二等奖（第四位）
3. 2017年，国家百千万人才工程，有突出贡献中青年专家
4. 国家杰出青年基金获得者（2015）
5. 山东省杰出青年科学基金获得者（2012）
6. 2007年，山东省“泰山学者”特聘专家
