2025年度
1. Feng Y#, Cheng X#, Yang Y, Liu C, Shi Y, Qi X, Zhao W, Liu B, Chen T*, Gao Chengjiang*. TBK1 phagosomal recruitment enhances antifungal immunity via positive feedback regulation with SRC. Cell Rep. 2025, 44(7):115972.
2. Cao L, Zhang J, Yu L, Yang W, Qi W, Ren R, Liu Y, Hou Y, Cao Y, Li Q, Wang X, Zhang Z, Li B, Sui W, Zhang Y, Gao Chengjiang*, Zhang C*, Zhang M*. E3 ubiquitin ligase Listerin regulates macrophage cholesterol efflux and atherosclerosis by targeting ABCA1. J Clin Invest. 2025, 135(16):e186509.
3. Qin F#, Cao R#, Bai X, Yuan J, Sun W, Zheng Y, Qi X, Zhao W, Liu B*, Gao Chengjiang*. Listerin Alleviates Alzheimer's Disease through IRE1-mediated Decay of TLR4 mRNA. Adv Sci (Weinh). 2025, e14956.
4. Zheng Y, Gao Chengjiang*. Proteasome: An antibiotic arsenal in anti-bacterial innate immunity. Mol Cell. 2025, 85(10):1894-1896.
5. Bai X, Dong N, Cao N, Zhou M, Yuan J, Zhang Y, Liu Y, Zhang J, Chen T, Liu F, Sun W, Zheng Y, Zhao W, Shu Q, Gao Chengjiang*, Liu B*. ZNF593 regulates the cGAS-mediated innate immune response by attenuating cGAS-DNA binding. Cell Death Differ. 2025, 32(10):1845-1858.
6. Sun W#, Wu H#, Zhao G, Shui Q, Zhang L, Luan X, Chen T, Liu F, Zheng Y, Zhao W, Qi X, Liu B, Gao Chengjiang*. Lipid droplets restrict phagosome formation in antifungal immunity. Cell Mol Immunol. 2025, 22(5):468-484.
7. Liu Y, Zhang X, Yu L, Cao L, Zhang J, Li Q, Wang X, Qi W, Cai L, Ren R, Wang W, Guo X, Su G, Xi B, Zhang Y, Gao Chengjiang*, Zhang M*, Zhang C*. E3 ubiquitin ligase RNF128 promotes Lys63-linked polyubiquitination on SRB1 in macrophages and aggravates atherosclerosis. Nat Commun. 2025, 16(1):2185.
8. Qin F, Cao R, Cui W, Bai X, Yuan J, Zhang Y, Liu Y, Cao N, Dong N, Zhou M, Chen T, Liu F, Sun W, Zheng Y, Zhao W, Liu B*, Gao Chengjiang*. Listerin promotes α-synuclein degradation to alleviate Parkinson's disease through the ESCRT pathway. Sci Adv. 2025, 11(7):eadp3672.
9. Song X, Liu T, Yu L, Ji Q, Guo X, Zong R, Li Y, Huang G, Xue Q, Fu Q, Liu B, Zheng Y, Chen L, Gao Chengjiang*, Liu H*. OTUD5 Protects Dopaminergic Neurons by Promoting the Degradation of α-Synuclein in Parkinson's Disease Model. Adv Sci (Weinh). 2025, 12(7):e2406700.
10. Shao Z, Wang L, Cao L, Chen T, Jia XM, Sun W*, Gao Chengjiang*, Xiao H*. The protein segregase VCP/p97 promotes host antifungal defense via regulation of SYK activation. PLoS Pathog. 2024, 20(10):e1012674.
11.Yang M, Cui W, Lv X, Xiong G, Sun C, Xuan H, Ma W, Cui X, Cheng Y, Han L*, Chu B*. S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism.Nat Commun. 2025 Jan 8;16(1):509. *通讯作者
12. Zhu L, Cui X, Xu H, Yang M, Han L*. The E3 ubiquitin ligase TRIM56 promotes aggregation and activation of Src protein through Lys63-linked polyubiquitination in hepatocellular carcinoma. Cell Death Dis. 2025 Oct 16;16(1):731.*通讯作者
2024年度
1. Zhang Z, Ren C, Xiao R, Ma S, Liu H, Dou Y, Fan Y, Wang S, Zhan P, Gao C, Yue X, Li C, Gao L, Liang X, Wu Z**,Ma C**. Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity.Sci Immunol. 2024 Nov 15;9(101):eadp7302.
2. Wang T##, Fan Y##, Tan S, Wang Z, Li M, Guo X, Yu X, Lin Q, Song X, Xu L, Li L, Li S, Gao L, Liang X**, Li C**,Ma C**. Probiotics and their metabolite spermidine enhance IFN-γ+CD4+ T cell immunity to inhibit hepatitis B virus.Cell Rep Med. 2024 Nov 19;5(11):101822.
3. Chen C##, Zhao F##, Peng J##, Zhao D##, Xu L, Li H, Ma S, Peng X, Sheng X, Sun Y, Wang T, Dong H, Ding Y, Wu Z, Liang X, Gao L, Wang H,Ma C**, Li C**. Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance.Cell Rep Med. 2024 Aug 20;5(8):101686.
4. Ren C, Zhang Z, Dou Y, Sun Y, Fu Z, Wang L, Wang K, Gao C, Fan Y, Sun S, Yue X, Li C, Gao L, Liang X,Ma C**, Wu Z**. DNA Sensor ABCF1 Phase Separates With cccDNA to Inhibit Hepatitis B Virus Replication.Adv Sci(Weinh). 2024 Dec;11(48):e2409485.
5. Ma S##, Wu Q##, Wu W##, Tian Y, Zhang J, Chen C, Sheng X, Zhao F, Ding L, Wang T, Zhao L, Xie Y, Wang Y, Yue X, Wu Z, Wei J, Zhang K, Liang X, Gao L, Wang H, Wang G**, Li C**,Ma C**. Urolithin A hijacks ERK1/2-ULK1 cascade to improve CD8+ T cell fitness for antitumor immunity. Adv Sci.2024 Mar 6:e2310065.
6. Xiao R##, Tian Y##, Zhang J, Li N, Qi M, Liu L, Wang J, Li Z, Zhang J, Zhao F, Wang T, Tan S, Li C, Wu Z, Yu M, Jiang X, Zhan P, Gao L, Han B**, Liu X**, Liang X**,Ma C**. Increased Siglec-9/Siglec-9L interactions on NK cells predict poor HCC prognosis and present a targetable checkpoint for immunotherapy.J Hepatol. 2024 Feb 7:S0168-8278(24)00106-5.
7. Chen, N., Zhao, M., Wu, N., Guo, Y., Cao, B., Zhan, B., Li, Y., Zhou, T., Zhu, F., Guo, C.,, Q., Li Yan*, Lining Zhang* . ACSS2 controls PPARγ activity homeostasis to potentiate adipose-tissue plasticity. Cell Death Differ ，2024，31:479 – 496
8. Guo Y, Chen N, Zhao M, Cao B, Zhu F, Guo C, Shi Y, Wang Q, Li Y, Zhang L. D-arabinose acts as antidepressant by activating the ACSS2-PPARγ/TFEB axis and CRTC1 transcription. Pharmacol Res. 2024 ;202:107136.
9. Y. Li, B.Zhan, X.Zhuang, M.Zhao, X.Chen, Q. Wang, Q. Liu, L. Zhang*, Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARγ/IL-10 signaling, J Neuroinflammation ，2024，21(1) 143.
10. Chen N, Wang X, Guo Y, Zhao M, Cao B, Zhan B, Li Y, Zhou T, Zhu F, Guo C, Shi Y, Wang Q, Zhang L, Li Y. IL-37d suppresses Rheb-mTORC1 axis independently of TCS2 to alleviate alcoholic liver disease. Commun Biol. 2024， 21;7(1):756
11 .Cao B, Chen X, Li Y, Zhou T, Chen N, Guo Y, Zhao M, Guo C, Shi Y, Wang Q, Du X, Zhang L*, Li Y*. PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson's disease. NPJ Parkinsons Dis. 2024， 6;10(1):146.
12 .N. Chen, X. Xu, Y. Guo, M. Zhao, Y. Li, T. Zhou, X. Zhang, J. Gao, F. Zhu, C. Guo, Y. Shi, Q. Wang, W. Wu, L. Zhang*, Y. Li*, Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ-TPH2 Axis. Research 2024，7 0400.
13.Y. Guo, Y. Zhang, Y. Guan, N. Chen, M. Zhao, Y. Li, T. Zhou, X. Zhang, F. Zhu, C. Guo, Y. Shi, Q. Wang, L. Zhang*, Y. Li*, IL-37d enhances COP1-mediated C/EBPβ degradation to suppress spontaneous neutrophil migration and tumor progression. Cell Rep， 2024，43, 113787 .
14. Zhao Z, Song X, Wang Y, Yu L, Huang G, Li Y, Zong R, Liu T, Ji Q, Zheng Y, Liu B, Zhu Q, Chen L, Gao Chengjiang*, Liu H*. E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model. Cell Death Differ. 2024, 31(11):1410-1421.
15. Zhang X, Han L, Hou J, Yang H, Xu H, Li G, Shu Q, Zhu D*, Zheng Y*, Gao Chengjiang*. Stress granule-localized USP8 potentiates cGAS-mediated type I interferonopathies through deubiquitination of DDX3X. Cell Rep. 2024, 43(6):114248.
16. Liu Y, Yuan J, Zhang Y, Qin F, Bai X, Sun W, Chen T, Liu F, Zheng Y, Qi X, Zhao W, Liu B*, Gao Chengjiang*. OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation. Cell Death Differ. 2024, 31(6):753-767.
17. Zhao G, Li Y, Chen T, Liu F, Zheng Y, Liu B, Zhao W, Qi X, Sun W*, Gao Chengjiang*. TRIM26 alleviates fatal immunopathology by regulating inflammatory neutrophil infiltration during Candida infection. PLoS Pathog. 2024, 20(1):e1011902.
18. Qin F, Cai B, Cao R, Bai X, Yuan J, Zhang Y, Liu Y, Chen T, Liu F, Sun W, Zheng Y, Qi X, Zhao W, Liu B*, Gao Chengjiang*. Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS-mediated immune response. Proc Natl Acad Sci U S A. 2023, 120(52):e2308853120.
19. Qin F, Cai B, Wang P, Cao R, Zhang Y, Wen H, Zheng Y, Zhao W, Gao Chengjiang*, Liu B*. LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway. Autophagy. 2024, 20(6):1270-1285.
20. Ma D, Yang M, Sun C, Cui X, Xiong G, Wang Q, Jing W, Chen H, Lv X, Liu S, Li T, Zhao Y, Han L*. cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity. Cell Death Differ. 2024 Jun;31(6):722-737. *通讯作者
2023年度
1. Liu F, Zhuang W, Song B, Yang Y, Liu J, Zheng Y, Liu B, Zheng J, Zhao W, Gao Chengjiang*. MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade. Cell Mol Immunol. 2023, 20(10):1186-1202.
2. Chen T, Feng Y, Sun W, Zhao G, Wu H, Cheng X, Zhao F, Zhang L, Zheng Y, Zhan P, Zhao W, Liu B, Gao Chengjiang*. The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity. Immunity. 2023, 56(8):1727-1742.
3. Zheng Y, Zhang X, Gao Chengjiang*. PI4P STimulatING innate immune activation: beyond the Golgi. Cell Mol Immunol. 2023, 20(12):1399-1400.
4. Kong L, Sui C, Chen T, Zhang L, Zhao W, Zheng Y, Liu B, Cheng X*, Gao Chengjiang*. The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus. Cell Rep. 2023, 42(4):112306.
5. Liu H#, Yan Z#, Zhu D, Xu H, Liu F, Chen T, Zhang H, Zheng Y, Liu B, Zhang L, Zhao W, Gao Chengjiang*. CD-NTase family member MB21D2 promotes cGAS-mediated antiviral and antitumor immunity. Cell Death Differ. 2023, 30(4):992-1004.
6. Ma S##, Tian Y##, Peng J##, Chen C, Peng X, Zhao F, Li Z, Li M, Zhao F, Sheng X, Zong R, Li Y, Zhang J, Yu M, Zhu Q, Tian X, Li Y, Neckenig MR, Liu H, Zhan P, Yue X, Wu Z, Gao L, Liang X, Liu X**, Li C**,Ma C**. Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models.Sci Transl Med. 2023 Nov 15;15(722):eadg6752. (IF=16.9).国际期刊Trends in Molecular Medicine (IF = 14.5)为该论文配发热点推荐（spotlight）文章“TIM-3 inhibitors: a promising strategy for tumor immunotherapy”
7. Zhang Y, Fan Y, Hu H, Zhang X, Wang Z, Wu Z, Wang L, Yu X, Song X, Xiang P, Zhang X, Wang T, Tan S, Li C, Gao L, Liang X, Li S, Li N, Yue X**,Ma C**.ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.Nat Commun. 2023 Nov 18;14(1):7527.
8. Tan S##, Wang Z##, Li N, Guo X, Zhang Y, Ma H, Peng X, Zhao Y, Li C, Gao L, Li T, Liang X**,Ma C**. Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response.Cell Death Differ. 2023 Sep;30(9):2104-2119.
9. Tian P, Yang W, Guo X, Wang T, Tan S, Sun R, Xiao R, Wang Y, Jiao D, Xu Y, Wei Y, Wu Z, Li C, Gao L,Ma C**, Liang X**. Early life gut microbiota sustains liver-resident natural killer cells maturation via the butyrate-IL-18 axis.Nat Commun. 2023 Mar 27;14(1):1710.
10. Jiao D, Sun R, Ren X, Wang Y, Tian P, Wang Y, Yuan D, Yue X, Wu Z, Li C, Gao L,Ma C**, Liang X**. Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity.Cell Rep. 2023 Oct 31;42(10):113211.
11. Wu Z##, Lei X##, Wang X##, Zhang Z, Li Y, Gao L, Liang X, Wang P, Wang J**,Ma C**. Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection.Signal Transduct Target Ther.2023 Jan 18;8(1):19.
2022年度及之前
Zhao J, Cai B, Shao Z, Zhang L, Zheng Y, Ma C, Yi F, Liu B, Gao C. TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1. Cell Death Differ. 2021 May 20. doi: 10.1038/s41418-021-00803-1. Epub ahead of print. PMID: 34017102.
Chen X, Guan Y, Zhang Y, Jia Y, Li W, Guo C, Li Y, Wang X, Shi Y, Wang Q, Zhu F, Li Y, Zhang L. Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation. Cell Death Differ. 2021 Apr;28(4):1237-1250. doi: 10.1038/s41418-020-00646-2. Epub 2020 Oct 25. PMID: 33100324; PMCID: PMC8026996.
Hou J, Han L, Zhao Z, Liu H, Zhang L, Ma C, Yi F, Liu B, Zheng Y, Gao C. USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS. Nat Commun. 2021 May 20;12(1):2970. doi: 10.1038/s41467-021-23219-4. PMID: 34016972.
Ma D, Yang M, Wang Q, Sun C, Shi H, Jing W, Bi Y, Shen X, Ma X, Qin Z, Lin Y, Zhu L, Zhao Y, Cheng Y, Han L. Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response. Sci Adv. 2021 Mar 24;7(13):eabc1834. doi: 10.1126/sciadv.abc1834. PMID: 33762328; PMCID: PMC7990331.
Wu Z, Ma H, Wang L, Song X, Zhang J, Liu W, Ge Y, Sun Y, Yu X, Wang Z, Wang J, Zhang Y, Li C, Li N, Gao L, Liang X, Yue X, Ma C. Tumor suppressor ZHX2 inhibits NAFLD-HCC progression via blocking LPL-mediated lipid uptake. Cell Death Differ. 2020 May;27(5):1693-1708. doi: 10.1038/s41418-019-0453-z. Epub 2019 Nov 18. PMID: 31740790; PMCID: PMC7206072.
Li Y, Jia Y, Wang D, Zhuang X, Li Y, Guo C, Chu H, Zhu F, Wang J, Wang X, Wang Q, Zhao W, Shi Y, Chen W, Zhang L. Programmed cell death 4 as an endogenous suppressor of BDNF translation is involved in stress-induced depression. Mol Psychiatry. 2020 Mar 16. doi: 10.1038/s41380-020-0692-x. Epub ahead of print. PMID: 32203159.
Tan S, Xu Y, Wang Z, Wang T, Du X, Song X, Guo X, Peng J, Zhang J, Liang Y, Lu J, Peng J, Gao C, Wu Z, Li C, Li N, Gao L, Liang X, Ma C. Tim-3 Hampers Tumor Surveillance of Liver-Resident and Conventional NK Cells by Disrupting PI3K Signaling. Cancer Res. 2020 Mar 1;80(5):1130-1142. doi: 10.1158/0008-5472.CAN-19-2332. Epub 2019 Dec 17. PMID: 31848194.
Zhu L, Qin C, Li T, Ma X, Qiu Y, Lin Y, Ma D, Qin Z, Sun C, Shen X, Zhao Y, Han L. The E3 ubiquitin ligase TRIM7 suppressed hepatocellular carcinoma progression by directly targeting Src protein. Cell Death Differ. 2020 Jun;27(6):1819-1831. doi: 10.1038/s41418-019-0464-9. Epub 2019 Dec 4. PMID: 31802035; PMCID: PMC7244582.
Liu B, Zhang M, Chu H, Zhang H, Wu H, Song G, Wang P, Zhao K, Hou J, Wang X, Zhang L, Gao C. The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination. Nat Immunol. 2017 Feb;18(2):214-224. doi: 10.1038/ni.3641. Epub 2016 Dec 19. PMID: 27992402.
Song H, Liu B, Huai W, Yu Z, Wang W, Zhao J, Han L, Jiang G, Zhang L, Gao C, Zhao W. The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3. Nat Commun. 2016 Dec 8;7:13727. doi: 10.1038/ncomms13727. PMID: 27929086; PMCID: PMC5155141.
Song G, Liu B, Li Z, Wu H, Wang P, Zhao K, Jiang G, Zhang L, Gao C. E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1. Nat Immunol. 2016 Dec;17(12):1342-1351. doi: 10.1038/ni.3588. Epub 2016 Oct 24. PMID: 27776110.