刘素侠,医学博士/ 博士后,教授,硕士生导师
1997年7月毕业于山东医科大学医学免疫学专业,获医学硕士学位,留校任教至今。2004年7月获得免疫学博士学位,2006至2007年赴美国肯塔基大学访问交流,先后在Dr. Spielmann和Dr. Gong的实验室分别从事基因治疗和糖尿病发病机制的研究,2007年在山东大学临床医学博士后流动站研究动脉粥样硬化的免疫学机制,2009年以来与美国宾西法尼亚大学实验室合作,主要致力于TIPE家族分子与炎症/肿瘤的相关研究。以第一作者或通讯作者发表SCI收录论文十数篇,申请获批国家发明专利2项,先后承担国家自然基金2项、省级科研课题6项、校级科研课题2项。
研究方向
目前主要从事TIPE家族分子与HBV相关肝病、动脉粥样硬化免疫学机制的相关研究
主要发表论文(*通讯作者)
1.Hao C(#), Zhang N(#), Geng M, Ren Q, Li Y, Wang Y, Chen YH, and Liu S(*). Clinical Significance of TIPE2 Protein Upregulation in Non-Hodgkin’s Lymphoma. J Histochem Cytochem. 2016 Sep;64:556–564.
2. Zhang G(#), Zhao L, Wang Y, Shao J, Cui J, Lou Y, GengM, Zhang N, Chen YH,Liu S(*) . TIPE2 protein prevents injury-induced restenosis in mice. BiochimicaetBiophysicaActa. 2015, 1852: 1574-1584
3. Zhang W(#), Zhang J(#), Zhao L, Shao J, Cui J, Guo C, Zhu F, Chen YH, Liu S(*). TIPE2 protein negatively regulates HBV-specific CD8+ T lymphocyte functions in humans. Mol Immunol. 2015 Mar; 64(1):204-9.
4. Cui J(#), Hao C(#), Zhang W, Shao J, Zhang N, Zhang G, Liu S(*). The Identical Expression Profiling of Human and Murine TIPE3 Protein Reveals Links to Its Functions. J Histochem Cytochem. 2015 Mar; 63(3):206-16.
5. Lou Y(#), Zhang G(#), Geng M, Zhang W, Cui J, Liu S(*). TIPE2 negatively regulates inflammation by switching arginine metabolism from nitric oxide synthase to arginase. PLoS One. 2014;9(5):e96508.
6. Lou Y(#), Sun H(#), Morrissey S, Porturas T, Liu S, Hua X, Chen YH(*). Critical roles of TIPE2 protein in murine experimental colitis.J Immunol. 2014 Aug 1;193(3):1064-70.
7. Lou Y(#), Liu S(#)(*), Zhang C, Zhang G, Li J, Ni M, An G, Dong M, Liu X, Zhu F, Zhang W, Gao F, Chen YH(*), Zhang Y(*). Enhanced atherosclerosis in TIPE2-deficient mice is associated with increased macrophage responses to oxidized low-density lipoprotein. J Immunol. 2013;191(9):4849-57.
8. Zhang G(#), Zhang W, Lou Y, Xi W, Cui J, Geng M, Zhu F, Chen YH, Liu S(*). TIPE2 deficiency accelerates neointima formation by downregulating smooth muscle cell differentiation. Cell Cycle. 2013;12(3):501-10.
9. Xi W(#), Hu Y(#), Liu Y(#), Zhang J, Wang L, Lou Y, Qu Z, Cui J, Zhang G, Liang X, Ma C, Gao C, Chen YH, Liu S(*). Roles of TIPE2 inHepatitis B Virus-induced Hepatic Inflammation in Humans and Mice. MolImmunol, 2011;48 (9-10):1203-1208.
10. Lou Y(#) and Liu S(*). The TIPE (TNFAIP8) family in inflammation, immunity, and cancer.MolImmunol, 2011;49:4-7.
11. Cui J(#), Zhang G(#), Hao C(#), Wang Y, Lou Y, Zhang W, Wang J, Liu S(*). The expression of TIPE1 inmurine tissues and human cell lines.MolImmunol, 2011;48(12-13):1548-55.
12. Zhang G(#), Hao C(#), Lou Y(#), Xi W, Wang X, Wang Y, Qu Z, Guo C, Chen YH, Zhang Y, and Liu S(*). Tissue-specific Expression of TIPE2 Provides Insights into Its Function. MolImmunol 2010;47:2435-2442.
13. 席文锦(#),王艳,娄运伟,张佳慧,梁拓,章桂忠,张然熙,刘素侠(*)。CPI-17调控血管平滑肌表型对动脉粥样硬化形成的影响。山东大学学报(医学版),2010;48(6):13-16.
14. Subramanian T(#), Liu S(#) (Co-first author), Troutman JM, Andres DA, Spielmann HP. Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity. Chembiochem(IF=3.945). 2008;9(17):2872-82.
15. Liu Y(#), Liu S, Liang X, Zhang Q, Gao L, Han L,Cao Y, Hou N, Du J, Sun W(*). Blockade of TRAIL pathway ameliorates HBV-induced hepatocyte apoptosis in an acute hepatitis model. BiochemBiophys Res Commun. 2007 (352):329–334.
16. 刘素侠(#),孙汶生(*),郭春,张向红,张艳,姜昱竹。互补于hTERT关键区段的反义RNA抑制肝癌细胞研究,基础医学与临床,2006;26(4):381-385.
主要承担的科研项目
1、山东省科技攻关计划,2016GSF201017,新型凋亡诱导分子TIPE1防治肝纤维化的机制及初步应用,2016.9-2018.90,1万元。
2、国家自然基金面上项目,81171578,新型抗炎蛋白TIPE2调控HBV特异性CD8+T功能参与乙型病毒性肝炎机制研究,2012.1.1-2015.12.31,58万元。
3、国家自然基金青年基金,81100205,新型抗炎蛋白TIPE2调控巨噬细胞功能抗动脉粥样硬化的机制研究,2012.1.1-2014.12.31,23万元。