王群,女,博士,山东大学基础医学院免疫学系副教授,硕士生导师
Email: wangqun@sdu.edu.cn
教育经历:
2006/9–2009/12,山东大学,医学院免疫学系,医学博士
2000/8–2003/6,山东大学,医学院免疫学系,医学硕士
1990/9–1995/6,青岛大学医学院,医学学士
科研工作经历:
2010/12-至今,山东大学,基础医学院免疫学系,副教授
2008/10-2009/10,美国贝勒医学院,医学系,博士后
2004/9-2010/11,山东大学,医学院免疫学系,讲师
2003/7-2004/9,山东大学,医学院免疫学系,助教
1995/7-2000/9,山东省胸科医院,住院医师
研究兴趣:
肥胖是2型糖尿病、脂肪肝、心血管疾病甚至癌症等发病的重要风险因素,肥胖诱发慢性炎症所致胰岛素抵抗及高血压、高血糖、高血脂等系列代谢综合征是上述肥胖相关疾病发生发展的关键环节。针对以上问题,目前研究工作主要围绕两个方面展开:
1. 肥胖及相关炎症和代谢综合征的免疫学机制及干预策略
2. 脂肪间充干细胞对免疫相关炎症及肥胖相关代谢紊乱的调控作用
发表论文(*通讯作者):
1. Bai Y, Dong Z, Shang Q, Zhao H, Wang L, Guo C, Gao F, Zhang L, Wang Q*. Pdcd4 Is Involved in the Formation of Stress Granule in Response to Oxidized Low-Density Lipoprotein or High-Fat Diet. PLoS One. 2016 Jul 25;11(7):e0159568.
2. Bai Y, Shang Q, Zhao H, Pan Z, Guo C, Zhang L, Wang Q*. Pdcd4 restrains the self-renewal and white-to-beige transdifferentiation of adipose-derived stem cells. Cell Death Dis. 2016 Mar 31;7:e2169.
3. Shang Q, Bai Y, Wang G, Song Q, Guo C, Zhang L, Wang Q*. Delivery of Adipose-Derived Stem Cells Attenuates Adipose Tissue Inflammation and Insulin Resistance in Obese Mice Through Remodeling Macrophage Phenotypes. Stem Cells Dev. 2015 Sep 1;24(17):2052-64.
4. Liu C, Shang Q, Bai Y, Guo C, Zhu F, Zhang L, Wang Q*. Adenosine A2A receptor, a potential valuable target for controlling reoxygenated DCs-triggered inflammation. Mol Immunol. 2015 Feb;63(2):559-65.
5. Shang Q, Dong Z, Liu C, Bai Y, Guo C, Zhang L, Wang Q*. Differential effects of agonistic 4-1BB (CD137) monoclonal antibody on the maturation and functions of hypoxic dendritic cells. Int Immunopharmacol. 2014 Dec;23(2):609-16.
6. Wang Q*, Dong Z, Liu X, Song X, Song Q, Shang Q, Jiang Y, Guo C, Zhang L*. Programmed cell death-4 deficiency prevents diet-induced obesity, adipose tissue inflammation, and insulin resistance. Diabetes. 2013 Dec;62(12):4132-43. doi: 10.2337/db13-0097. Epub 2013 Aug 29
7. Wang Q, Perrard XD, Perrard JL, Mansoori A, Raya JL, Hoogeveen R, Smith CW, Ballantyne CM, Wu H. Differential effect of weight loss with low-fat diet or high-fat diet restriction on inflammation in the liver and adipose tissue of mice with diet-induced obesity. Atherosclerosis. 2011 Nov; 219(1):100-8.
8. Wang Q, Perrard XD, Perrard JL, Mansoori A, Smith CW, Ballantyne CM, Wu H. Effect of the cannabinoid receptor-1 antagonist rimonabant on inflammation in mice with diet-induced obesity. Obesity. 2011 Mar; 19(3):505-13.
9. Wang Q#, Liu C#, Zhu F, Liu F, Zhang P, Guo C, Wang X, Li H, Ma C, Sun W, Zhang Y, Chen W, Zhang L. Reoxygenation of hypoxia-differentiated dentritic cells induces Th1 and Th17 cell differentiation. Mol Immunol. 2010 Jan;47(4):922-31. Epub 2009 Nov 12. (#共同第一作者)
10. Liu C#, Wang Q#, Liu F, Li H, Zhu F, Wang X, Guo C, Ma C, Zhang L. The allogeneic but not syngeneic dendritic cells effectively generated regulatory T cells from total CD4+ population without exogenous cytokines. Scand J Immunol. 2010 Jan;71(1):12-9. Published Online: 30 Sep 2009. PubMed PMID: 20017805. (#共同第一作者)
11. Wang Q*, Zhang P, Zhang Q, Wang X, Li J, Ma C, Sun W, Zhang L. Analysis of CD137 and CD137L expression in human primary tumor tissues. Croat Med J. 2008 Apr;49(2):192-200. PubMed PMID: 18461674; PubMed Central PMCID: PMC2359873.
承担课题(项目负责人):
1. ADSC通过重塑抗炎性M2样巨噬细胞抑制肥胖相关炎症的作用及机制研究(81471065). 国家自然基金. 2015.1-2018.12. 65万.
2. PDCD4通过调节内质网应激促进肥胖及相关炎症的作用及机制研究(81270923). 国家自然基金. 2013.1-2016.12. 70万.
3. 乏氧微环境对CD4+CD25+调节性T细胞数量及功能的影响(30700729). 国家自然基金. 2008.1-2010.12. 17万. (结题)
4. 脂肪基质细胞外泌小体用于肥胖相关代谢紊乱治疗的研究(2016GSF201005).山东省重点研发计划. 2016.1-2018.12. 10万.
5. 以腺苷酸受体为靶点调控再氧合DC介导的免疫炎性反应(2011BSE27110). 山东省优秀中青年科学家科研奖励基金. 2011.7-2014.7. 6万. (结题)
6. 乏氧微环境中CD4+CD25+调节性T细胞数量及功能的变化(Q2007C02). 山东省自然基金. 2007.12-2010.12. 4.5万. (结题)
7. PDCD4对饮食诱导肥胖及其相关炎症的作用研究(2012TS111). 山东大学自主创新基金. 6万. 2012.1-2014.12. 7万. (结题)